TNFα Mechanically Sensitizes Masseter Muscle Afferent Fibers
نویسندگان
چکیده
1 2 TNFα Mechanically Sensitizes Masseter Muscle Afferent Fibers 3 of Male Rats 4 5 6 Akhlaq W. Hakim, Xu-Dong Dong, Peter Svensson, Ujendra Kumar, Brian E. Cairns 7 8 1 Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British 9 Columbia, V6T 1Z3, Canada 10 2 Department of Clinical Oral Physiology, School of Dentistry, Århus University, DK-8000 11 Århus C, Denmark 12 13 14 Running title: TNFα-induced nociceptor sensitization 15 16 Correspondence should be addressed to: 17 18 Brian E. Cairns, Ph.D. 19 Faculty of Pharmaceutical Sciences 20 The University of British Columbia 21 2146 East Mall, Vancouver, British Columbia 22 V6T 1Z3 CANADA 23 Phone: 1-604-822-7715 24 Fax: 1-604-822-3035 25 Email: [email protected] 26 27
منابع مشابه
TNF α Mechanically Sensitizes Masseter Muscle Nociceptors by 2 Increasing Prostaglandin E 2 Levels
1 TNFα Mechanically Sensitizes Masseter Muscle Nociceptors by 2 Increasing Prostaglandin E2 Levels. 3 4 5 Akhlaq W. Hakim, Xudong Dong, Brian E. Cairns 6 7 Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, 8 V6T 1Z3, Canada 9 10 11 12 13 14 Running title: TNFα-induced nociceptor sensitization 15 16 17 18 19 20 Correspondence should be addressed...
متن کاملTNF Mechanically Sensitizes Masseter Muscle Afferent Fibers of Male Rats
Hakim AW, Dong XD, Svensson P, Kumar U, Cairns BE. TNF mechanically sensitizes masseter muscle afferent fibers of male rats. J Neurophysiol 102: 1551–1559, 2009. First published June 24, 2009; doi:10.1152/jn.00326.2009. Behavioral evidence in rats indicates that injection of tumor necrosis factor alpha (TNF ) into skeletal muscle results in a prolonged mechanical sensitization without gross inf...
متن کاملTNFα mechanically sensitizes masseter muscle nociceptors by increasing prostaglandin E2 levels.
TNFα induces mechanical sensitization of rat masseter muscle nociceptors, which takes 2-3 h to manifest and is mediated through activation of P55 and P75 receptors. This study was undertaken to determine whether TNFα induces nociceptor mechanical sensitization through the release of other algogenic substances such as glutamate, prostaglandin E(2) (PGE(2)), and/or nerve growth factor (NGF), whic...
متن کاملThe Role of Glutamate and Peripheral N-Methyl-D- Aspartate (NMDA) Receptors in Masticatory Muscle Pain Mechanisms
Citation for published version (APA): Cairns, B. E. (2016). The role of glutamate and peripheral N-Methyl-D-Aspartate (NMDA) receptors in masticatory muscle pain mechanisms. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recogn...
متن کاملفعالیت فیبرهای گاما در وضعیت استراحت و هنگام کشش های فازیک و تونیک در دوک عضلانی دم Rat
Background and Purpose: Basically, The muscle spindle is innervated by γ – fibers, γ – fibers are divided into phasic and tonic groups on the basis of their function. Ït is believed that phasic one γ innervate all the muscle spindle fibers where as tonic one innervate only tonic muscle spindle fibers and phasic of type two. The purpose of this study was to observe the fiber activity during ph...
متن کامل